CD/白细胞分化抗原/细胞膜表面分化抗原群的定义及意义
CD(Cluster of differentiation)就是细胞膜表面的分化抗原群/分化抗原簇,应用聚类分析,可将来自不同实验室识别同一分化抗原的单克隆抗体归为一个CD,经由从1982年第1次国际上人类白细胞分化抗原会议(The Human Leucocyte Differentiation Antigen workshop,HLDA) 统一命名。迄今为至,人CD的序号已从CD1命名至CD350 (2009年),可大致划分为T细胞、B细胞、髓细胞、NK细胞、血小板、粘附分子、内皮细胞、细胞因子受体、激活抗原、碳水化合物半抗原、树突状细胞、干细胞/祖细胞、基质细胞和红细胞14个组。白细胞分化抗原(Leucocyte Differentiation Antigen,LDA)是指不同谱系(1ineage)血细胞在正常分化,成熟,活化过程中出现或消失的细胞表面标志,多是跨膜蛋白或糖蛋白,少数为碳水化合物半抗原。随着人类功能基因组计划研究以及免疫学与其他学科的交叉,人类白细胞分化抗原的概念逐渐被人类细胞分化分子(HCDM)所替代。
采用单克隆抗体鉴定方法识别的白细胞分化抗原又称CD (cluster of differentiation) 抗原。 检测CD 抗原是实验室识别细胞及不同分化阶段细胞或细胞亚群最主要的方法。白细胞分化抗原(狭义上的CD)参与机体重要的生理和病理过程:①免疫应答过程中免疫细胞的相互识别,免疫细胞抗原识别、活化、增殖和分化,免疫效应功能的发挥;②造血细胞的分化和造血过程的调控;③参与炎症反应、血栓形成和组织修复;④参与细胞的生长、分化、迁移,及肿瘤的恶化和转移。
CD在基础免疫学研究中主要应用于:①CD抗原的基因克隆,新CD抗原及新配体的发现;②CD抗原结构与功能关系;③细胞激活途径和膜信号的传导;④细胞分化过程中的调控;⑤细胞亚群的功能。CD在临床免疫学研究中主要用于:①机体免疫功能的检测;②白血病、淋巴瘤免疫分型;③免疫毒素用于肿瘤治疗、骨髓移植以及移植排斥反应的防治;④体内免疫调节治疗。
在许多场合下,抗体及其识别的相应抗原都用同一个CD序号,因此在参阅教科书和文献时需加注意:(1)CD是流水编号,CD129暂缺;CD67和CD66b是重复的;CD187-190,CD211,CD237,CD341-343,CD345-248暂未编号。(2)CD中带有w的抗原或抗体CDw12,CDw198,CDw199,CDw293尚需继续进行全面鉴定。(3)有些CD抗原又可进一步划分为不同的成员,一般用小写英文字母表示,但情况有所不同:①如CD1可分为CD1a,CD1b和CD1c,
这三种不同分子是分别由三个不同的高度同源的基因所编码;②CD45至少可分为CD45RA,CD45RB,CD45RC和CD45RO,它们是同一基因的不同异型/同种型(isoform);③CD2和CD2R是识别同一个分子上不同的表位;④CD49已进一步划分为CD49a,D49b,CD49c,CD49d,CD49e和CD49f,它们的基因定位于不同的染色体上,但具有较高的同源性。(4)CD的组划分的特异性是相对的,实际上,许多CD抗原的组织细胞分布较为广泛。此外,有的CD抗原可由不同的分类角度而归入不同的组,如IL-2受体a链CD25是活化T细胞的标记,也属于细胞因子受体;再如某些属于T细胞、B细胞、髓细胞或NK细胞组的CD抗原实际上也是粘附分子,等等。
CD 主要抗原表达(Main Antigen Expression)/其他名字/分子量(kDa)
CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12
CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12
CD1c Cortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12
CD2 T cells, NK cells LFA-2, E-Rosette Receptor 50
CD2R Activated T cells 50
CD3 T cells 16,20,25-28
CD4 Helper-inducer T cells, Monocytes, Macrophages 56
CD5 T cells, B cell subset 67
CD6 T cells, B cell subset 105
CD7 T cells 40
CD8 Cytotoxic/Suppressor T cells, NK cells 32-34
CD9 Platelets, Monocytes, Pre-B cells 24
CD10 Pre-B cells, Granulocytes CALLA 100
CD11a Leukocytes LFA-1, αL Integrin 180
CD11b Granulocytes, Monocytes, NK cells MAC-1, αM Integrin, CR3 170
CD11c Granulocytes, Monocytes, NK cells, T cell subset, B cell subset, αX Integrin 150 CDw12 Granulocytes, Monocytes 90-120
CD13 Granulocytes, Monocytes Aminopeptidase N 130
CD14 Monocytes 55
CD15 Granulocytes, Monocytes Lewis X CHO
CD15s Neutrophils Sialyl Lewis X CHO
CD15u Myeloid subset Sulfated Lewis X CHO
CD16a NK cells, Macrophages FcRIII A 50-65
CD16b Granulocytes FcRIII B 48
CD17 Granulocytes, Monocytes, Platelets Lactosylceramide -
CD18 Leukocytes (Platelets negative) β2 Integrin 95
CD19 B cells 90
CD20 B cells 33,35,37
CD21 B cells subset, Follicular dendritic cells CR2 145
CD22 B cells 140
CD23 B cell subset, Eosinophils, Platelets FcεRII 50-45
CD24 B cells, Granulocytes 41/38
CD25 Activated T cells IL-2Rα Chain 55
CD26 T cell subset, Macrophages 110
CD27 T cell subset 55
CD28 T cell subset 44
CD29 Leukocytes β1 Integrin 130
CD30 Activated T and B cells, Reed Sternberg cells Ki-1 105
CD31 Platelets, Monocytes, Granulocytes, B cells PECAM-1, GPIIa 140
CD32 Monocytes, Neutrophils, B cells, Eosinophils FcRII 40
CD33 Myeloid Progenitor cells, Monocytes 67
CD34 Hematopoietic Progenitor cells 105-120
CD35 Monocytes, B cells, Granulocytes CR1 160,190,220,250
CD36 Monocytes, Platelets GPIV (IIIb) 88
CD37 B cells 52-40
CD38 Activated T cells, Plasma cells 45
CD39 B cells, Monocytes 100-70
CD40 B cells, Monocytes, Carcinoma cells 48/44
CD41 Platelets, Megakaryocytes GPIIb/IIIa, αIIb Integrin 120
CD42a Platelets, Megakaryocytes GPIX 23
CD42b Platelets, Megakaryocytes GPIB-a 135,23
CD42c Platelets, Megakaryocytes GPIB-b 22
CD42d Platelets, Megakaryocytes GPV 85
CD43 T cells, Granulocytes, Monocytes Leukosialin 90-100
CD44 Leukocytes, Erythrocytes H-CAM, Pgp-1 8-90
CD44R (Varied-dependent upon Exon Splicing)
CD45 Leukocytes Leukocyte Common Antigen 180,190,205,220
CD45RA B cells, T cell subset, Monocytes 220,205
CD45RB B cells, T cell subset, Monocytes 190,205,220
CD45RC B cells, T cell subset 190,205,220
CD45RO B cells, T cell subset, Monocytes 180
CD46 Ubiquitous (Erythrocytes negative) Membrane Cofactor Protein 66,56
CD47 Ubiquitous 47-52
CD47R Broad 47-52
CD48 Leukocytes 43
CD49a Activated T cells VLA-1, α1 Integrin 210
CD49b B cells, Monocytes, Platelets VLA-2, α2 Integrin 160
CD49c B cells VLA-3, α3 Integrin 125
CD49d Lymphocytes, Monocytes, Eosinophils VLA-4, α4 Integrin 150,80,70
CD49e T cell subset, Monocytes, Platelets VLA-5, α5 Integrin 132/25
CD49f T cell subset, Monocytes VLA-6, α6 Integrin 120/25
CD50 Leukocytes ICAM-3 124
CD51 Platelets αV Integrin 125/25
CD51/61 Platelets, Osteoclasts, Endothelial cells complex
CD52 Leukocytes CAMPATH-1 21-28
CD53 Leukocytes 32-40
CD54 Endothelial cells, Various activated cells ICAM-1 90
CD55 Broad Decay Accelerating Factor 75
CD56 NK cells N-CAM 220/135
CD57 NK cells, T cell subset HNK-1 110
CD58 Broad LFA-3 65-70
CD59 Broad Protectin, Homologous Restriction Factor 18-20
CD60a T cell subset, platelets GD3 CHO
CD60b T cell subset, activated B cells 9-0-sialyl GD3 CHO
CD60c T cell subset 7-0-sialyl GD3 CHO
CD61 Platelets, Megakaryocytes β3 Integrin, GPIIIa 110
CD62E Endothelial cells E-Selectin, ELAM-1 140
CD62L Lymphocytes, Monocytes, NK cells L-Selectin, LECAM-1 150
CD62P Activated Platelets, Endothelial cells P-Selectin, LECAM-3 75-80
CD63 Activated Platelets, Monocytes 53
CD64 Monocytes FcRI 75
CD65 Neutrophils
CD65s Neutrophils, Monocytes
CD66a Neutrophils Biliary Glycoprotein 160-180
CD66b Granulocytes CGM6 95-100
CD66c Neutrophils, Colon carcinoma NCA 90
CD66d Neutrophils CGM1 30
CD66e Colon epithelial CEA 180-200
CD66f Pregnancy Specific Glycoprotein
CD67 (Re-assigned to CD66b) (重复CD66b)
CD68 Monocytes, Macrophages 110
CD69 Activated T and B cells, NK cells Activation Inducer Molecule 34/28
CD70 Activated T and B cells, Reed-Sternberg cells 75,95,170
CD71 Proliferating cells Transferrin Receptor 95
CD72 B cells 43/39
CD73 B & T cell subset ECTO-5' Nucleotidase 69
CD74 B cells, Monocytes Invariant Chain 41,35,33
CD75 B cell subset, Epithelial Lactosamines CHO
CD75s B cell subset α-2, 6-sialylated Lactosamines CHO
CD77 Activated B cells, Endothelial cells
CD79a B cells MB-1 33,40
CD79b B cells B29 33,40
CD80 Activated B cells B7-1 60
CD81 B cells, T cells, Neutrophils TAPA-1 22
CD82 Leukocytes, Platelets 50-53
CD83 Dendritic cells, Activated lymphocytes HB15 43
CD84 Monocytes, Platelets, B cells 73
CD85 Dendritic cells, Monocytes, B cells see note 1 in notes section 110
CD86 Monocytes, Activated B cells B7-2 80
CD87 Granulocytes, Monocytes, Activated T cells UPA Receptor 50-65
CD88 Granulocytes C5a Receptor 42
CD89 Neutrophils, Monocytes Fcα Receptor 55-70
CD90 Progenitor cell subset, Thymic Stromal cells THY-1 18
CD91 Monocytes α2 Macroglobulin Receptor 600
CD92 Neutrophils, Monocytes, Platelets, Endothelial cells 70
CD93 Neutrophils, Monocytes, Endothelial cells 120
CD94 NK cells, T cell subset 30
CD95 Apoptotic cells FAS 42
CD96 Activated T cells Tactile 160
CD97 Activated T cells CD55 Ligand 74,80,89
CD98 Monocytes, T cells, B cells 4F2 80,40
CD99 Lymphocytes, Thymocytes 32
CD99R T cells, NK cells, Myeloid cells 32
CD100 Broad 150
CD101 Granulocytes, Monocytes, Activated T cells 140
CD102 Lymphocytes, Monocytes ICAM-2 60
CD103 Intra Epithelial Lymphocytes HML-1, αE Integrin 150,25
CD104 Epithelial, Schwann cells β4 Integrin 220
CD105 Endothelial cells Endoglin 95
CD106 Activated Endothelial cells VCAM-1 100-110
CD107a Activated Platelets LAMP-1 110
CD107b Activated Platelets LAMP-2 120
CD108 Activated splenic T cells 80
CD109 Activated T cells, Platelets, Endothelial cells Platelet Activation Factor 170/150
CD110Stem cell subset,Megakaryocytes,Platelets (v. weak) Thrombopoietin Receptor, Mpl 82-84 CD111 Stem cell subset, Macrophages, Neutrophils PRR/Nectin-1 64-72
CD112 Monocytes, Neutrophils, Stem cell subset PRR2/Nectin-2 64-72
CD113 Epithelial cells, Placenta PRR3, Nectin-3 83
CD114 Granulocytes, Monocytes G-CSF Receptor 95,139
CD115 Monocytes, Macrophages M-CSF Receptor 150
CD116 Monocytes, Neutrophils, Eosinophils GM-CSF Receptor αChain 60
CD117 Progenitor cells SCF-Receptor, c-kit 145
CD118 Epithelial cells LIF Receptor 190
CD119 Monocytes, B cells, Epithelial cells IFN γ Receptor 90
CD120a Monocytes, Granulocytes TNF Receptor, Type 1 55
CD120b Monocytes, Granulocytes, TNF Receptor, Type 2 75
Activated lymphocytes
CD121a T cells, Fibroblasts, Endothelial cells IL-1 Receptor, Type 1 80
CD121b B cells, Monocytes, Macrophages IL-1 Receptor, Type 2 68
CD122 T cell subset, NK cells IL-2 Receptor β Chain 75
CD123 Progenitor cells, Granulocytes, Monocytes, Megakaryocytes, IL-3 Receptor α Chain 70 CD124 B cells, T cells, Progenitor cells IL-4/IL-13 Receptor 140
CD125 Eosinophils, Basophils IL-5 Receptor α Chain 60
CD126 Plasma cells, Activated B cells IL-6 Receptor α Chain 80
CD127 Early B cells, T cells, Progenitor cells, Monocytes, IL-7 Receptor α Chain 65-75 CD129 Not assigned
CD130 Plasma cells, Activated B cells gp130Receptor Subunit for IL-6,IL-11,LIF, OSM, LNTF,CT-1 130
CD131 Myeloid cells Common β Chain for IL-3, IL-5, GM-CSF Receptor 120
CD132 Broad Common γ Chain for IL-2, IL-4, IL-7, IL-9, IL-15 Receptors 64
CD133 Stem cell subset AC-133 120
CD134 Activated T cell subset OX40 48-50
CD135 Progenitor cell subset Flt3/FIk2 130-150
CD136 Epithelial cells Macrophage Stimulating Protein Receptor 180
CD137 T cell subset 4-1BB 30
CD138 Plasma cells, Epithelial cells SYNDECAN-1 20
CD139 Germinal center B cells 209,228
CD140a (Undetectable on most normal cells) PDGF Receptor α 180
CD140b Endothelial cell subset, Stromal cells PDGF Receptor β 180
CD141 Endothelial cells Thrombomodulin 100
CD142 Activated Monocytes and Endothelial cells Tissue Factor 45
CD143 Endothelial cell subset Angiotensin Converting Enzyme 170
CD144 Endothelial cells VE-CADHERIN 135
CDw145 Endothelial cells, Some stromal cells 25,90,110
CD146 Endothelial cells, Activated T cells MUC18/S-endo 118
CD147 Endothelial cells, Monocytes, T cell subset, Platelets, Erythrocytes, Neurothelin/Basigin 50-60
CD148 Hematopoietic cells HPTP-ETA/DEP-1
CD150 T cell subset, B cell subset, Thymocytes SLAM 70
CD151 Platelets, Endothelial cells PETA-3 27
CD152 Activated T cells CTLA-4 44
CD153 Activated T cells CD30 Ligand 40
CD154 Activated T cells, Mast cells, Basophils CD40 Ligand 33
CD155 Monocytes, Macrophages, Thymocytes Poliovirus Receptor 80-90
CD156a Monocytes, Macrophages, Granulocytes ADAM8 60
CD156b Broad TACE/ADAM17 85
CD156c Broad ADAM-10 98
CD157 Monocytes, Neutrophils, Endothelial cells BST-1 42-45
CD158 T cell subset, NK cell subset see note 2 in notes section
CD158a NK cells, T cell subset p58.1, P50.1 50,58
CD158b NK cells, T cell subset p58.2, p50-2 50,58
CD159a NK cells NKG2a 43
CD159c NK cells NKG2C 40
CD160 T cell subset, NK cell subset By55 26
CD161 NK cells, T cell subset NKR-P1 60
CD162 T cells, Monocytes, Granulocytes, B cell subset PSGL-1 110
CD162R NK cell subset PEN5 CHO
CD163 Monocytes KiM4 130
CD164 T cells, Monocytes, Granulocytes, B cell subset, Progenitor cells MGC-24 80
CD165 Thymocytes, Thymic epithelial cells AD2/gp37 37
CD166 Activated Lymphocytes, Endothelial cells, Fibroblasts ALCAM, CD6 Ligand 100
CD167a Epithelial cells, Myoblasts Discoidin Domain Receptor, DDR1 120
CD168 Thymocyte subset, T cell subset, Monocytes RHAMM 84-88
CD169 Macrophage subset Sialoadhesin 185
CD170 Macrophage subset, Neutrophils Siglec-5 140
CD171 Monocytes, T cell subset, B cells L1 200
CD172a Monocytes, T cell subset, Stem cells SIRP α 110
CD172b Monocytes, Dendritic cells SIRP β1 50
CD172g T cells, Activated NK cells SIRP γ, SIRP β2 45-50
CD173 Red cells, Stem cell subset, Platelets Blood group H type 2 CHO
CD174 Stem cell subset, Epithelial cells Lewis Y CHO
CD175 Stem cell subset TN CHO
CD175s Erythroblasts Sialyl-Tn CHO
CD176 Stem cell subset Thomson-Friedrenreich antigen CHO
CD177 Neutrophil subset NB1 56-62
CD178 Activated T cells Fas ligand 38-42
CD179a Pro-B cells, Pre-B cells V pre beta 16
CD179b Pro-B cells, Pre-B cells Lambda 5 22
CD180 B cell subset, Monocytes, Dendritic cells Rp105/Bgp 95 95-105
CD181 Neutrophils, T cell subset CXCR1 39
CD182 Monocytes, Granulocytes, T cell subset CXCR2 40
CD183 Activated T cells, Activated NK cells CXCR3 40
CD184 T cell subset, B cells, Monocytes, Dendritic cells, Endothelial cells, CXCR4 45
CD185 B cells, T cell subset CXCR5 45
CD186 T cell subset CXCR6, BONZO 40
CD191 T cells, Monocytes, Stem cell subset CCR1 39
CD192 Monocytes, T cell subset, B cells, Basophils, Endothelial cells, CCR2 40
CD193 Eosinophils, Basophils, T cell subset, Dendritic cell subset, CCR3 45
CD194 T cells, Bascphils, Platelets, Monocytes (low) CCR4 41
CD195 Monocytes, T cell subset CCR5 45
CD196 T cell subset, B cells, Dendritic cell subset CCR6 45
CD197 T cell subset CCR7 45
CDw198 T cell subset, Monocytes CCR8 50
CDw199 T cell subset CCR9 50
CD200 Thymocytes, B cells, Endothelium, Activated T cells OX-2 45-50
CD201 Endothelial cell subset Endothelial cell Protein C Receptor(EPCR) 50
CD202b Endothelial cells, Stem cells Tie/Tek 150
CD203c Basophils, Megakaryocytes NPP3 130-150
CD204 Macrophages Macrophage Scavenger Receptor 220
CD205 Dendritic cells, Thymic epithelium DEC-205 205
CD206 Dendritic cell subset, Macrophages, Monocytes Macrophage Mannose Receptor 180
CD207 Immature langerhans cells Langerin 40
CD208 Interdigitating dendritic cells DC-LAMP 70-90
CD209 Dendritic cell subset DC-SIGN 44
CDw210 T cells, B cells, NK cells, Monocytes, Macrophages IL-10R 90-110
CD212 Activated T cells, Activated NK cells IL-12Rβ1 100
CD213a1 B cells, Monocytes, Fibroblasts, Endothelial cells IL-13Rα1 65
CD213a2 B cells, Monocytes IL-13Rα2 65
CD217 Broad IL-17R 120
CD218a Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rα 70
CD218b Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rβ 70
CD220 Broad Insulin Receptor 140 + 70
CD221 Broad IGF-1 Receptor 140 + 70
CD222 Broad IGF-2 Receptor/ Mannose-6-phosphate Receptor 250
CD223 Activated T cells, Activated NK cells LAG-3 70
CD224 Leukocytes, Stem cells Gamma Glutamyl Transferase (GGT) 27, 68
CD225 Broad Leu-13 17
CD226 T cells, NK cells, Monocytes, Platelets DNAM-1 65
CD227 Stem cell subset, Epithelial cells MUC-1 300
CD228 Stem cells, Melanoma cells Melanotransferrin 80-95
CD229 T cells, B cells Ly-9 95, 110
CD230 Broad Prion Protein 35
CD231 T cell leukemia, Neuroblastoma TALLA-1 30-45
CD232 Broad VESPR (Plexin C1) 200
CD233 Red cells Band 3 90
CD234 Red cells Duffy 35-45
CD235a Red cells Glycophorin A 36
CD235b Red cells Glycophorin B 20
CD236 Stem cell subset, Red cells Glycophorin C/D 32/23
CD236R Stem cell subset, Red cells Glycorphorin C 32
CD238 Stem cell subset, Red cells Kell 93
CD239 Stem cell subset, Red cells B-CAM, Lutheran 78-85
CD240CE Red cells Rhesus 30 CE 30-32
CD240D Red cells Rhesus 30 D 30-32
CD241 Red cells Rhesus 50 Glycoprotein 50
CD242 Red cells ICAM-4 42
CD243 Stem cells MDR-1 180
CD244 NK cells, T cell subset 2B4 70
CD245 T cell subset p220/240 220-240
CD246 Anaplastic T cell leukemia Anaplastic Lymphoma Kinase 80
CD247 T cells, NK cells TCR zeta chain 16
CD248 Stromal Fibroblasts, Tumor endothelium Endosialin 175
CD249 Endothelial cells, Epithelial cells Aminopeptidase A 160
CD250 Reserved for TNF
CD251 Reserved for lymphotoxin
CD252 Dendritic cells, Endothelial cells, Activated B cells OX40 Ligand 34
CD253 Activated T cells, Activated B cells, Activated monocytes TRAIL 33-34
CD254 Activated T cells, Stromal cells, Osteoblasts TRANCE, RANKL 35
CD255 Reserved for TWEAK
CD256 Myeloid cells APRIL 16
CD257 Myeloid cells BlyS, BAFF 45
CD258 Activated T cells, Immature dendritic cells LIGHT 28
CD259 Reserved for NGF
CD260 Reserved for lymphotoxin beta receptor
CD261 Leukocytes (very weak), Tumor cells TRAIL-R1, APO2 57
CD262 Broad TRAIL-R2, DR5 60
CD263 Broad (weak) TRAIL-R3, DcR1 65
CD264 Broad TRAIL-R4, DcR2 35
CD265 Broad, Osteoclasts, Dendritic cells RANK, TRANCE-R 97
CD266 HUVEC TWEAK-R 14
CD267 B cells (weak), Activated T cells TACI 32
CD268 B cells, T cells (weak) BAFF-R 25
CD269 B cells BCMA 27
CD270 Reserved for LIGHTR
CD271 Neurons, Stromal cells, Follicular dendritic cells NGFR 75
CD272 Th1 cells BTLA
CD273 Dendritic cells, Activated T cells, Activated monocytes B7-DC, PD-L2 25
CD274 Dendritic cells, Activated T cells, Activated monocytes B7-H1, PD-L1 40
CD275 Dendritic cells, B cells (weak), T cells (weak), Activated monocytes, ICOSL 60
CD276 Dendritic cell subset, Activated monocytes B7-H3 (long) 40-45
CD277 T cells, B cells, NK cells, Monocytes, Dendritic cells, Stem cell, BT3.1, BTF5 56
CD278 Activated T cells ICOS, AILIM 56
CD279 Activated T cells, Activated B cells PD1 55
CD280 Myeloid progenitors, Fibroblasts, Endothelial cell subset, Macrophage subset, Endo180, TEM22 180 CD281 Monocytes, Neutrophils TLR1, TIL 90
CD282 Monocytes, Neutrophils TLR2, TIL4 85
CD283 Fibroblasts, Dendritic cells TLR3 100
CD284 Monocytes (weak) TLR4 85
CD285 Reserved for TLR5
CD286 Monocytes, Dendritic cells, Endothelial cells TLR6 92
CD287 Reserved for TLR7
CD288 Peripheral blood leukocytes, Monocytes, Dendritic cells TLR8 120
CD289 Dendritic cell subset, Activated B cells TLR9 115-120
CD290 B lymphocytes, Dendritic cells TLR10 95
CD291 Reserved for TLR11
CD292 Bone progenitor cells BMPR1A 50-58
CDw293 Bone progenitor cells BMPR1B 50-58
CD294 Th2 cells, Eosinophils, Basophils CRTH2, GPR44 55-70
CD295 Broad, Monocytes (weak) LEPR, OBR 130-150
CD296 Epithelial cells, Muscle, T cell subset, Myeloid cell subset ART1 37
CD297 Red cells, Erythroblasts, Activated monocytes ART4, Dombrock Blood Group 38
CD298 Broad Na,K ATPase β3 Subunit 52
CD299 Endothelial cell subset DC-SIGNR, L-SIGN 45
CD300a Dendritic cells, Monocytes, Lymphocyte subsets CMRFH 60
CD300c Dendritic cells, Monocytes, Lymphocyte subsets CMRF35A
CD300e Monocytes CMRF35L1
CD301 Immature dendritic cells MGL, CLECSF14 38
CD302 Granulocytes, Monocytes, Dendritic cells DCL1 30
CD303 Dendritic cell subset BDCA2 38
CD304 Dendritic cell subset BDCA4, Neuropilin 140
CD305 NK cells, T cells, B cells, Monocytes LAIR-1 40
CD306 Putative secreted protein LAIR-2
CD307 B cell subset IRTA2, FcRH5 100
CD308 Reserved for VEGFR1
CD309 Endothelial cells, Stem cell subsets VEGFR2, FLK1, KDR 230
CD310 Reserved for VEGFR3
CD311 Reserved for EMR1
CD312 Neutrophils, Monocytes, DC subset, Macrophages, Activated lymphocytes, EMR2 90 CD313 Reserved for EMR3
CD314 NK cells, T cell subset NKG2D 42
CD315 B cell subset, Activated monocytes CD9P1, SMAP6 135
CD316 B cells, T cells, NK cells (weak) EWI2, IgSF8 63
CD317 B cells, T cells, Monocytes, NK cells, Dendritic cells BST2, HM1.24 29-33 CD318 Stem cell subset CDCP1, SIMA135 135
CD319 NK cells, T cell subset, B cell subset, Dendritic cell subset CRACC, SLAMF7 66 CD320 Follicular dendritic cells 8D6
CD321 Broad JAM-1, F-11R 32-35
CD322 Endothelial cells, Monocytes, B cells, T cell subset JAM-2, VE-JAM 45 CD323 Reserved for JAM-3
CD324 Epithelial cells, Stem cells, Erythroblasts E-Cadherin, Cadherin 1 120 CD325 Neurons, Endothelial cells, Stem cells N-Cadherin, Cadherin 2 140 CD326 Epithelial cells Ep-CAM 40
CD327 B cells, Trophoblasts Siglec6, OB-BP1
CD328 NK cells, Monocytes, T cell subset Siglec7, AIRM1 75
CD329 Monocytes, Granulocytes, NK cells Siglec9
CD330 Reserved for Siglec10
CD331 Fibroblasts, Epithelial cells FGFR1, FLT2 130
CD332 Fibroblasts, Epithelial cells FGFR2, KGFR 115-135
CD333 Fibroblasts, Epithelial cells FGFR3, JTK4 115-135
CD334 Fibroblasts, Epithelial cells FGFR4, JTK2 110
CD335 NK cells NKp46, NCR1, Ly94 46
CD336 NK cells NKp44, NCR2, Ly95 44
CD337 NK cells NKp30, NCR3, Ly117 30
CD338 Stem cell subset ABCG2, BCRP 72
CD339 Stromal cells, Epithelial cells, Jagged1, JAG1 150
CD340 Stem cell subset, HER-2 185
CD344 Stem cell subset, Broad, FZD4 60
CD349 Stem cell subset, Broad, FZD9 64
CD350 Stem cell subset, Broad, FZD10 65
CD/白细胞分化抗原/细胞膜表面分化抗原群的定义及意义
CD(Cluster of differentiation)就是细胞膜表面的分化抗原群/分化抗原簇,应用聚类分析,可将来自不同实验室识别同一分化抗原的单克隆抗体归为一个CD,经由从1982年第1次国际上人类白细胞分化抗原会议(The Human Leucocyte Differentiation Antigen workshop,HLDA) 统一命名。迄今为至,人CD的序号已从CD1命名至CD350 (2009年),可大致划分为T细胞、B细胞、髓细胞、NK细胞、血小板、粘附分子、内皮细胞、细胞因子受体、激活抗原、碳水化合物半抗原、树突状细胞、干细胞/祖细胞、基质细胞和红细胞14个组。白细胞分化抗原(Leucocyte Differentiation Antigen,LDA)是指不同谱系(1ineage)血细胞在正常分化,成熟,活化过程中出现或消失的细胞表面标志,多是跨膜蛋白或糖蛋白,少数为碳水化合物半抗原。随着人类功能基因组计划研究以及免疫学与其他学科的交叉,人类白细胞分化抗原的概念逐渐被人类细胞分化分子(HCDM)所替代。
采用单克隆抗体鉴定方法识别的白细胞分化抗原又称CD (cluster of differentiation) 抗原。 检测CD 抗原是实验室识别细胞及不同分化阶段细胞或细胞亚群最主要的方法。白细胞分化抗原(狭义上的CD)参与机体重要的生理和病理过程:①免疫应答过程中免疫细胞的相互识别,免疫细胞抗原识别、活化、增殖和分化,免疫效应功能的发挥;②造血细胞的分化和造血过程的调控;③参与炎症反应、血栓形成和组织修复;④参与细胞的生长、分化、迁移,及肿瘤的恶化和转移。
CD在基础免疫学研究中主要应用于:①CD抗原的基因克隆,新CD抗原及新配体的发现;②CD抗原结构与功能关系;③细胞激活途径和膜信号的传导;④细胞分化过程中的调控;⑤细胞亚群的功能。CD在临床免疫学研究中主要用于:①机体免疫功能的检测;②白血病、淋巴瘤免疫分型;③免疫毒素用于肿瘤治疗、骨髓移植以及移植排斥反应的防治;④体内免疫调节治疗。
在许多场合下,抗体及其识别的相应抗原都用同一个CD序号,因此在参阅教科书和文献时需加注意:(1)CD是流水编号,CD129暂缺;CD67和CD66b是重复的;CD187-190,CD211,CD237,CD341-343,CD345-248暂未编号。(2)CD中带有w的抗原或抗体CDw12,CDw198,CDw199,CDw293尚需继续进行全面鉴定。(3)有些CD抗原又可进一步划分为不同的成员,一般用小写英文字母表示,但情况有所不同:①如CD1可分为CD1a,CD1b和CD1c,
这三种不同分子是分别由三个不同的高度同源的基因所编码;②CD45至少可分为CD45RA,CD45RB,CD45RC和CD45RO,它们是同一基因的不同异型/同种型(isoform);③CD2和CD2R是识别同一个分子上不同的表位;④CD49已进一步划分为CD49a,D49b,CD49c,CD49d,CD49e和CD49f,它们的基因定位于不同的染色体上,但具有较高的同源性。(4)CD的组划分的特异性是相对的,实际上,许多CD抗原的组织细胞分布较为广泛。此外,有的CD抗原可由不同的分类角度而归入不同的组,如IL-2受体a链CD25是活化T细胞的标记,也属于细胞因子受体;再如某些属于T细胞、B细胞、髓细胞或NK细胞组的CD抗原实际上也是粘附分子,等等。
CD 主要抗原表达(Main Antigen Expression)/其他名字/分子量(kDa)
CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12
CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12
CD1c Cortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12
CD2 T cells, NK cells LFA-2, E-Rosette Receptor 50
CD2R Activated T cells 50
CD3 T cells 16,20,25-28
CD4 Helper-inducer T cells, Monocytes, Macrophages 56
CD5 T cells, B cell subset 67
CD6 T cells, B cell subset 105
CD7 T cells 40
CD8 Cytotoxic/Suppressor T cells, NK cells 32-34
CD9 Platelets, Monocytes, Pre-B cells 24
CD10 Pre-B cells, Granulocytes CALLA 100
CD11a Leukocytes LFA-1, αL Integrin 180
CD11b Granulocytes, Monocytes, NK cells MAC-1, αM Integrin, CR3 170
CD11c Granulocytes, Monocytes, NK cells, T cell subset, B cell subset, αX Integrin 150 CDw12 Granulocytes, Monocytes 90-120
CD13 Granulocytes, Monocytes Aminopeptidase N 130
CD14 Monocytes 55
CD15 Granulocytes, Monocytes Lewis X CHO
CD15s Neutrophils Sialyl Lewis X CHO
CD15u Myeloid subset Sulfated Lewis X CHO
CD16a NK cells, Macrophages FcRIII A 50-65
CD16b Granulocytes FcRIII B 48
CD17 Granulocytes, Monocytes, Platelets Lactosylceramide -
CD18 Leukocytes (Platelets negative) β2 Integrin 95
CD19 B cells 90
CD20 B cells 33,35,37
CD21 B cells subset, Follicular dendritic cells CR2 145
CD22 B cells 140
CD23 B cell subset, Eosinophils, Platelets FcεRII 50-45
CD24 B cells, Granulocytes 41/38
CD25 Activated T cells IL-2Rα Chain 55
CD26 T cell subset, Macrophages 110
CD27 T cell subset 55
CD28 T cell subset 44
CD29 Leukocytes β1 Integrin 130
CD30 Activated T and B cells, Reed Sternberg cells Ki-1 105
CD31 Platelets, Monocytes, Granulocytes, B cells PECAM-1, GPIIa 140
CD32 Monocytes, Neutrophils, B cells, Eosinophils FcRII 40
CD33 Myeloid Progenitor cells, Monocytes 67
CD34 Hematopoietic Progenitor cells 105-120
CD35 Monocytes, B cells, Granulocytes CR1 160,190,220,250
CD36 Monocytes, Platelets GPIV (IIIb) 88
CD37 B cells 52-40
CD38 Activated T cells, Plasma cells 45
CD39 B cells, Monocytes 100-70
CD40 B cells, Monocytes, Carcinoma cells 48/44
CD41 Platelets, Megakaryocytes GPIIb/IIIa, αIIb Integrin 120
CD42a Platelets, Megakaryocytes GPIX 23
CD42b Platelets, Megakaryocytes GPIB-a 135,23
CD42c Platelets, Megakaryocytes GPIB-b 22
CD42d Platelets, Megakaryocytes GPV 85
CD43 T cells, Granulocytes, Monocytes Leukosialin 90-100
CD44 Leukocytes, Erythrocytes H-CAM, Pgp-1 8-90
CD44R (Varied-dependent upon Exon Splicing)
CD45 Leukocytes Leukocyte Common Antigen 180,190,205,220
CD45RA B cells, T cell subset, Monocytes 220,205
CD45RB B cells, T cell subset, Monocytes 190,205,220
CD45RC B cells, T cell subset 190,205,220
CD45RO B cells, T cell subset, Monocytes 180
CD46 Ubiquitous (Erythrocytes negative) Membrane Cofactor Protein 66,56
CD47 Ubiquitous 47-52
CD47R Broad 47-52
CD48 Leukocytes 43
CD49a Activated T cells VLA-1, α1 Integrin 210
CD49b B cells, Monocytes, Platelets VLA-2, α2 Integrin 160
CD49c B cells VLA-3, α3 Integrin 125
CD49d Lymphocytes, Monocytes, Eosinophils VLA-4, α4 Integrin 150,80,70
CD49e T cell subset, Monocytes, Platelets VLA-5, α5 Integrin 132/25
CD49f T cell subset, Monocytes VLA-6, α6 Integrin 120/25
CD50 Leukocytes ICAM-3 124
CD51 Platelets αV Integrin 125/25
CD51/61 Platelets, Osteoclasts, Endothelial cells complex
CD52 Leukocytes CAMPATH-1 21-28
CD53 Leukocytes 32-40
CD54 Endothelial cells, Various activated cells ICAM-1 90
CD55 Broad Decay Accelerating Factor 75
CD56 NK cells N-CAM 220/135
CD57 NK cells, T cell subset HNK-1 110
CD58 Broad LFA-3 65-70
CD59 Broad Protectin, Homologous Restriction Factor 18-20
CD60a T cell subset, platelets GD3 CHO
CD60b T cell subset, activated B cells 9-0-sialyl GD3 CHO
CD60c T cell subset 7-0-sialyl GD3 CHO
CD61 Platelets, Megakaryocytes β3 Integrin, GPIIIa 110
CD62E Endothelial cells E-Selectin, ELAM-1 140
CD62L Lymphocytes, Monocytes, NK cells L-Selectin, LECAM-1 150
CD62P Activated Platelets, Endothelial cells P-Selectin, LECAM-3 75-80
CD63 Activated Platelets, Monocytes 53
CD64 Monocytes FcRI 75
CD65 Neutrophils
CD65s Neutrophils, Monocytes
CD66a Neutrophils Biliary Glycoprotein 160-180
CD66b Granulocytes CGM6 95-100
CD66c Neutrophils, Colon carcinoma NCA 90
CD66d Neutrophils CGM1 30
CD66e Colon epithelial CEA 180-200
CD66f Pregnancy Specific Glycoprotein
CD67 (Re-assigned to CD66b) (重复CD66b)
CD68 Monocytes, Macrophages 110
CD69 Activated T and B cells, NK cells Activation Inducer Molecule 34/28
CD70 Activated T and B cells, Reed-Sternberg cells 75,95,170
CD71 Proliferating cells Transferrin Receptor 95
CD72 B cells 43/39
CD73 B & T cell subset ECTO-5' Nucleotidase 69
CD74 B cells, Monocytes Invariant Chain 41,35,33
CD75 B cell subset, Epithelial Lactosamines CHO
CD75s B cell subset α-2, 6-sialylated Lactosamines CHO
CD77 Activated B cells, Endothelial cells
CD79a B cells MB-1 33,40
CD79b B cells B29 33,40
CD80 Activated B cells B7-1 60
CD81 B cells, T cells, Neutrophils TAPA-1 22
CD82 Leukocytes, Platelets 50-53
CD83 Dendritic cells, Activated lymphocytes HB15 43
CD84 Monocytes, Platelets, B cells 73
CD85 Dendritic cells, Monocytes, B cells see note 1 in notes section 110
CD86 Monocytes, Activated B cells B7-2 80
CD87 Granulocytes, Monocytes, Activated T cells UPA Receptor 50-65
CD88 Granulocytes C5a Receptor 42
CD89 Neutrophils, Monocytes Fcα Receptor 55-70
CD90 Progenitor cell subset, Thymic Stromal cells THY-1 18
CD91 Monocytes α2 Macroglobulin Receptor 600
CD92 Neutrophils, Monocytes, Platelets, Endothelial cells 70
CD93 Neutrophils, Monocytes, Endothelial cells 120
CD94 NK cells, T cell subset 30
CD95 Apoptotic cells FAS 42
CD96 Activated T cells Tactile 160
CD97 Activated T cells CD55 Ligand 74,80,89
CD98 Monocytes, T cells, B cells 4F2 80,40
CD99 Lymphocytes, Thymocytes 32
CD99R T cells, NK cells, Myeloid cells 32
CD100 Broad 150
CD101 Granulocytes, Monocytes, Activated T cells 140
CD102 Lymphocytes, Monocytes ICAM-2 60
CD103 Intra Epithelial Lymphocytes HML-1, αE Integrin 150,25
CD104 Epithelial, Schwann cells β4 Integrin 220
CD105 Endothelial cells Endoglin 95
CD106 Activated Endothelial cells VCAM-1 100-110
CD107a Activated Platelets LAMP-1 110
CD107b Activated Platelets LAMP-2 120
CD108 Activated splenic T cells 80
CD109 Activated T cells, Platelets, Endothelial cells Platelet Activation Factor 170/150
CD110Stem cell subset,Megakaryocytes,Platelets (v. weak) Thrombopoietin Receptor, Mpl 82-84 CD111 Stem cell subset, Macrophages, Neutrophils PRR/Nectin-1 64-72
CD112 Monocytes, Neutrophils, Stem cell subset PRR2/Nectin-2 64-72
CD113 Epithelial cells, Placenta PRR3, Nectin-3 83
CD114 Granulocytes, Monocytes G-CSF Receptor 95,139
CD115 Monocytes, Macrophages M-CSF Receptor 150
CD116 Monocytes, Neutrophils, Eosinophils GM-CSF Receptor αChain 60
CD117 Progenitor cells SCF-Receptor, c-kit 145
CD118 Epithelial cells LIF Receptor 190
CD119 Monocytes, B cells, Epithelial cells IFN γ Receptor 90
CD120a Monocytes, Granulocytes TNF Receptor, Type 1 55
CD120b Monocytes, Granulocytes, TNF Receptor, Type 2 75
Activated lymphocytes
CD121a T cells, Fibroblasts, Endothelial cells IL-1 Receptor, Type 1 80
CD121b B cells, Monocytes, Macrophages IL-1 Receptor, Type 2 68
CD122 T cell subset, NK cells IL-2 Receptor β Chain 75
CD123 Progenitor cells, Granulocytes, Monocytes, Megakaryocytes, IL-3 Receptor α Chain 70 CD124 B cells, T cells, Progenitor cells IL-4/IL-13 Receptor 140
CD125 Eosinophils, Basophils IL-5 Receptor α Chain 60
CD126 Plasma cells, Activated B cells IL-6 Receptor α Chain 80
CD127 Early B cells, T cells, Progenitor cells, Monocytes, IL-7 Receptor α Chain 65-75 CD129 Not assigned
CD130 Plasma cells, Activated B cells gp130Receptor Subunit for IL-6,IL-11,LIF, OSM, LNTF,CT-1 130
CD131 Myeloid cells Common β Chain for IL-3, IL-5, GM-CSF Receptor 120
CD132 Broad Common γ Chain for IL-2, IL-4, IL-7, IL-9, IL-15 Receptors 64
CD133 Stem cell subset AC-133 120
CD134 Activated T cell subset OX40 48-50
CD135 Progenitor cell subset Flt3/FIk2 130-150
CD136 Epithelial cells Macrophage Stimulating Protein Receptor 180
CD137 T cell subset 4-1BB 30
CD138 Plasma cells, Epithelial cells SYNDECAN-1 20
CD139 Germinal center B cells 209,228
CD140a (Undetectable on most normal cells) PDGF Receptor α 180
CD140b Endothelial cell subset, Stromal cells PDGF Receptor β 180
CD141 Endothelial cells Thrombomodulin 100
CD142 Activated Monocytes and Endothelial cells Tissue Factor 45
CD143 Endothelial cell subset Angiotensin Converting Enzyme 170
CD144 Endothelial cells VE-CADHERIN 135
CDw145 Endothelial cells, Some stromal cells 25,90,110
CD146 Endothelial cells, Activated T cells MUC18/S-endo 118
CD147 Endothelial cells, Monocytes, T cell subset, Platelets, Erythrocytes, Neurothelin/Basigin 50-60
CD148 Hematopoietic cells HPTP-ETA/DEP-1
CD150 T cell subset, B cell subset, Thymocytes SLAM 70
CD151 Platelets, Endothelial cells PETA-3 27
CD152 Activated T cells CTLA-4 44
CD153 Activated T cells CD30 Ligand 40
CD154 Activated T cells, Mast cells, Basophils CD40 Ligand 33
CD155 Monocytes, Macrophages, Thymocytes Poliovirus Receptor 80-90
CD156a Monocytes, Macrophages, Granulocytes ADAM8 60
CD156b Broad TACE/ADAM17 85
CD156c Broad ADAM-10 98
CD157 Monocytes, Neutrophils, Endothelial cells BST-1 42-45
CD158 T cell subset, NK cell subset see note 2 in notes section
CD158a NK cells, T cell subset p58.1, P50.1 50,58
CD158b NK cells, T cell subset p58.2, p50-2 50,58
CD159a NK cells NKG2a 43
CD159c NK cells NKG2C 40
CD160 T cell subset, NK cell subset By55 26
CD161 NK cells, T cell subset NKR-P1 60
CD162 T cells, Monocytes, Granulocytes, B cell subset PSGL-1 110
CD162R NK cell subset PEN5 CHO
CD163 Monocytes KiM4 130
CD164 T cells, Monocytes, Granulocytes, B cell subset, Progenitor cells MGC-24 80
CD165 Thymocytes, Thymic epithelial cells AD2/gp37 37
CD166 Activated Lymphocytes, Endothelial cells, Fibroblasts ALCAM, CD6 Ligand 100
CD167a Epithelial cells, Myoblasts Discoidin Domain Receptor, DDR1 120
CD168 Thymocyte subset, T cell subset, Monocytes RHAMM 84-88
CD169 Macrophage subset Sialoadhesin 185
CD170 Macrophage subset, Neutrophils Siglec-5 140
CD171 Monocytes, T cell subset, B cells L1 200
CD172a Monocytes, T cell subset, Stem cells SIRP α 110
CD172b Monocytes, Dendritic cells SIRP β1 50
CD172g T cells, Activated NK cells SIRP γ, SIRP β2 45-50
CD173 Red cells, Stem cell subset, Platelets Blood group H type 2 CHO
CD174 Stem cell subset, Epithelial cells Lewis Y CHO
CD175 Stem cell subset TN CHO
CD175s Erythroblasts Sialyl-Tn CHO
CD176 Stem cell subset Thomson-Friedrenreich antigen CHO
CD177 Neutrophil subset NB1 56-62
CD178 Activated T cells Fas ligand 38-42
CD179a Pro-B cells, Pre-B cells V pre beta 16
CD179b Pro-B cells, Pre-B cells Lambda 5 22
CD180 B cell subset, Monocytes, Dendritic cells Rp105/Bgp 95 95-105
CD181 Neutrophils, T cell subset CXCR1 39
CD182 Monocytes, Granulocytes, T cell subset CXCR2 40
CD183 Activated T cells, Activated NK cells CXCR3 40
CD184 T cell subset, B cells, Monocytes, Dendritic cells, Endothelial cells, CXCR4 45
CD185 B cells, T cell subset CXCR5 45
CD186 T cell subset CXCR6, BONZO 40
CD191 T cells, Monocytes, Stem cell subset CCR1 39
CD192 Monocytes, T cell subset, B cells, Basophils, Endothelial cells, CCR2 40
CD193 Eosinophils, Basophils, T cell subset, Dendritic cell subset, CCR3 45
CD194 T cells, Bascphils, Platelets, Monocytes (low) CCR4 41
CD195 Monocytes, T cell subset CCR5 45
CD196 T cell subset, B cells, Dendritic cell subset CCR6 45
CD197 T cell subset CCR7 45
CDw198 T cell subset, Monocytes CCR8 50
CDw199 T cell subset CCR9 50
CD200 Thymocytes, B cells, Endothelium, Activated T cells OX-2 45-50
CD201 Endothelial cell subset Endothelial cell Protein C Receptor(EPCR) 50
CD202b Endothelial cells, Stem cells Tie/Tek 150
CD203c Basophils, Megakaryocytes NPP3 130-150
CD204 Macrophages Macrophage Scavenger Receptor 220
CD205 Dendritic cells, Thymic epithelium DEC-205 205
CD206 Dendritic cell subset, Macrophages, Monocytes Macrophage Mannose Receptor 180
CD207 Immature langerhans cells Langerin 40
CD208 Interdigitating dendritic cells DC-LAMP 70-90
CD209 Dendritic cell subset DC-SIGN 44
CDw210 T cells, B cells, NK cells, Monocytes, Macrophages IL-10R 90-110
CD212 Activated T cells, Activated NK cells IL-12Rβ1 100
CD213a1 B cells, Monocytes, Fibroblasts, Endothelial cells IL-13Rα1 65
CD213a2 B cells, Monocytes IL-13Rα2 65
CD217 Broad IL-17R 120
CD218a Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rα 70
CD218b Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rβ 70
CD220 Broad Insulin Receptor 140 + 70
CD221 Broad IGF-1 Receptor 140 + 70
CD222 Broad IGF-2 Receptor/ Mannose-6-phosphate Receptor 250
CD223 Activated T cells, Activated NK cells LAG-3 70
CD224 Leukocytes, Stem cells Gamma Glutamyl Transferase (GGT) 27, 68
CD225 Broad Leu-13 17
CD226 T cells, NK cells, Monocytes, Platelets DNAM-1 65
CD227 Stem cell subset, Epithelial cells MUC-1 300
CD228 Stem cells, Melanoma cells Melanotransferrin 80-95
CD229 T cells, B cells Ly-9 95, 110
CD230 Broad Prion Protein 35
CD231 T cell leukemia, Neuroblastoma TALLA-1 30-45
CD232 Broad VESPR (Plexin C1) 200
CD233 Red cells Band 3 90
CD234 Red cells Duffy 35-45
CD235a Red cells Glycophorin A 36
CD235b Red cells Glycophorin B 20
CD236 Stem cell subset, Red cells Glycophorin C/D 32/23
CD236R Stem cell subset, Red cells Glycorphorin C 32
CD238 Stem cell subset, Red cells Kell 93
CD239 Stem cell subset, Red cells B-CAM, Lutheran 78-85
CD240CE Red cells Rhesus 30 CE 30-32
CD240D Red cells Rhesus 30 D 30-32
CD241 Red cells Rhesus 50 Glycoprotein 50
CD242 Red cells ICAM-4 42
CD243 Stem cells MDR-1 180
CD244 NK cells, T cell subset 2B4 70
CD245 T cell subset p220/240 220-240
CD246 Anaplastic T cell leukemia Anaplastic Lymphoma Kinase 80
CD247 T cells, NK cells TCR zeta chain 16
CD248 Stromal Fibroblasts, Tumor endothelium Endosialin 175
CD249 Endothelial cells, Epithelial cells Aminopeptidase A 160
CD250 Reserved for TNF
CD251 Reserved for lymphotoxin
CD252 Dendritic cells, Endothelial cells, Activated B cells OX40 Ligand 34
CD253 Activated T cells, Activated B cells, Activated monocytes TRAIL 33-34
CD254 Activated T cells, Stromal cells, Osteoblasts TRANCE, RANKL 35
CD255 Reserved for TWEAK
CD256 Myeloid cells APRIL 16
CD257 Myeloid cells BlyS, BAFF 45
CD258 Activated T cells, Immature dendritic cells LIGHT 28
CD259 Reserved for NGF
CD260 Reserved for lymphotoxin beta receptor
CD261 Leukocytes (very weak), Tumor cells TRAIL-R1, APO2 57
CD262 Broad TRAIL-R2, DR5 60
CD263 Broad (weak) TRAIL-R3, DcR1 65
CD264 Broad TRAIL-R4, DcR2 35
CD265 Broad, Osteoclasts, Dendritic cells RANK, TRANCE-R 97
CD266 HUVEC TWEAK-R 14
CD267 B cells (weak), Activated T cells TACI 32
CD268 B cells, T cells (weak) BAFF-R 25
CD269 B cells BCMA 27
CD270 Reserved for LIGHTR
CD271 Neurons, Stromal cells, Follicular dendritic cells NGFR 75
CD272 Th1 cells BTLA
CD273 Dendritic cells, Activated T cells, Activated monocytes B7-DC, PD-L2 25
CD274 Dendritic cells, Activated T cells, Activated monocytes B7-H1, PD-L1 40
CD275 Dendritic cells, B cells (weak), T cells (weak), Activated monocytes, ICOSL 60
CD276 Dendritic cell subset, Activated monocytes B7-H3 (long) 40-45
CD277 T cells, B cells, NK cells, Monocytes, Dendritic cells, Stem cell, BT3.1, BTF5 56
CD278 Activated T cells ICOS, AILIM 56
CD279 Activated T cells, Activated B cells PD1 55
CD280 Myeloid progenitors, Fibroblasts, Endothelial cell subset, Macrophage subset, Endo180, TEM22 180 CD281 Monocytes, Neutrophils TLR1, TIL 90
CD282 Monocytes, Neutrophils TLR2, TIL4 85
CD283 Fibroblasts, Dendritic cells TLR3 100
CD284 Monocytes (weak) TLR4 85
CD285 Reserved for TLR5
CD286 Monocytes, Dendritic cells, Endothelial cells TLR6 92
CD287 Reserved for TLR7
CD288 Peripheral blood leukocytes, Monocytes, Dendritic cells TLR8 120
CD289 Dendritic cell subset, Activated B cells TLR9 115-120
CD290 B lymphocytes, Dendritic cells TLR10 95
CD291 Reserved for TLR11
CD292 Bone progenitor cells BMPR1A 50-58
CDw293 Bone progenitor cells BMPR1B 50-58
CD294 Th2 cells, Eosinophils, Basophils CRTH2, GPR44 55-70
CD295 Broad, Monocytes (weak) LEPR, OBR 130-150
CD296 Epithelial cells, Muscle, T cell subset, Myeloid cell subset ART1 37
CD297 Red cells, Erythroblasts, Activated monocytes ART4, Dombrock Blood Group 38
CD298 Broad Na,K ATPase β3 Subunit 52
CD299 Endothelial cell subset DC-SIGNR, L-SIGN 45
CD300a Dendritic cells, Monocytes, Lymphocyte subsets CMRFH 60
CD300c Dendritic cells, Monocytes, Lymphocyte subsets CMRF35A
CD300e Monocytes CMRF35L1
CD301 Immature dendritic cells MGL, CLECSF14 38
CD302 Granulocytes, Monocytes, Dendritic cells DCL1 30
CD303 Dendritic cell subset BDCA2 38
CD304 Dendritic cell subset BDCA4, Neuropilin 140
CD305 NK cells, T cells, B cells, Monocytes LAIR-1 40
CD306 Putative secreted protein LAIR-2
CD307 B cell subset IRTA2, FcRH5 100
CD308 Reserved for VEGFR1
CD309 Endothelial cells, Stem cell subsets VEGFR2, FLK1, KDR 230
CD310 Reserved for VEGFR3
CD311 Reserved for EMR1
CD312 Neutrophils, Monocytes, DC subset, Macrophages, Activated lymphocytes, EMR2 90 CD313 Reserved for EMR3
CD314 NK cells, T cell subset NKG2D 42
CD315 B cell subset, Activated monocytes CD9P1, SMAP6 135
CD316 B cells, T cells, NK cells (weak) EWI2, IgSF8 63
CD317 B cells, T cells, Monocytes, NK cells, Dendritic cells BST2, HM1.24 29-33 CD318 Stem cell subset CDCP1, SIMA135 135
CD319 NK cells, T cell subset, B cell subset, Dendritic cell subset CRACC, SLAMF7 66 CD320 Follicular dendritic cells 8D6
CD321 Broad JAM-1, F-11R 32-35
CD322 Endothelial cells, Monocytes, B cells, T cell subset JAM-2, VE-JAM 45 CD323 Reserved for JAM-3
CD324 Epithelial cells, Stem cells, Erythroblasts E-Cadherin, Cadherin 1 120 CD325 Neurons, Endothelial cells, Stem cells N-Cadherin, Cadherin 2 140 CD326 Epithelial cells Ep-CAM 40
CD327 B cells, Trophoblasts Siglec6, OB-BP1
CD328 NK cells, Monocytes, T cell subset Siglec7, AIRM1 75
CD329 Monocytes, Granulocytes, NK cells Siglec9
CD330 Reserved for Siglec10
CD331 Fibroblasts, Epithelial cells FGFR1, FLT2 130
CD332 Fibroblasts, Epithelial cells FGFR2, KGFR 115-135
CD333 Fibroblasts, Epithelial cells FGFR3, JTK4 115-135
CD334 Fibroblasts, Epithelial cells FGFR4, JTK2 110
CD335 NK cells NKp46, NCR1, Ly94 46
CD336 NK cells NKp44, NCR2, Ly95 44
CD337 NK cells NKp30, NCR3, Ly117 30
CD338 Stem cell subset ABCG2, BCRP 72
CD339 Stromal cells, Epithelial cells, Jagged1, JAG1 150
CD340 Stem cell subset, HER-2 185
CD344 Stem cell subset, Broad, FZD4 60
CD349 Stem cell subset, Broad, FZD9 64
CD350 Stem cell subset, Broad, FZD10 65