第19卷 第3期甘肃科学学报Vol.19 No.3
2007年9月JournalofGansuSciencesSep.2007
TSGF与AFP对原发性肝癌的诊断特异性、
灵敏度分析
齐心亮,樊红艳,张 萍,朱小红,彭俊华,张华欣
(兰州军区兰州总医院检验科,甘肃兰州 730050)
摘 要: 分析探讨TSGF与AFP检测在原发性肝癌诊断中的特异性和灵敏度,以及对原发性肝癌的早期诊断价值.采用分光光度法检测TSGF,包括87例原发性肝癌(男性54、女性33例、平均年龄67岁)、67例继发性肝癌(男性42例、女性25例、平均年龄63岁),105例).其结果AFP.对照检测179例肝病患者的TSGF、AFP(肝硬化患者例TSGF对原发性肝癌的敏感性(86.2%)高于AFP(71.05);TSGF对继发性肝癌的敏感性(88.1%)高于AFP(35.8%)0.二者联合检测敏感性提高至94.3%.由此证明TSGF,对原发性肝癌其灵敏度高于AFP,特异性低于AFP.,对原发性肝
关键词: T;;特异性;分析
中图分类号: R13,P73517 文献标识码: A 文章编号:100420366(2007)0320088203
AnAnalysisofSpecificityandSensitivityofDiagnosisonPrimaryHepaticCarcinomabyDetectingTSGFandAFP
QIXin2liang,FANHong2yan,ZHANGPing,ZHUXiao2hong,PENGJun2hua,ZHANGHua2xin
(SectionInspectionofLaboratoryLanzhouGeneralHospital,LanzhouCommand,Lanzhou730050,China)
Abstract: OurobjectiveistoanalyzethespecificityandsensitivityofdiagnosisonprimaryhepaticThelevelofTSGFwasdetectedbythespectrophotometric
methodappliedto87primaryhepaticcarcinomapatients(male:54,female:33,averageage:67)and67secondumhepaticcarcinomapatients(male:42,female:25,averageage:63).Meanwhile,thelevelofAFPwasdetectedbythechemiluminescencemethod,andthelevelofTSGFandAFPweredetectedin179hepatopathycases(hepaticcirrhosis:74,chronictypeBhepatitis:105)ascomparison.Theresultsshow:thesensitivity(86.2%)ofdiagnosisonprimaryhepaticcarcinomabydetectingTSGFishigherthanthat(71.4%)bydetectingAFP,whichisstatisticallysignificant(P
: TSGF;AFP;primaryhepaticcarcinoma,specificity,analysiscarcinomabydetectingTSGFandAFP.
收稿日期:2006-01-30
恶性肿瘤特异生长因子TSGF(Tumorspecificgrowthfactor,TSGF)是近年来发现的一组与恶性肿瘤血管增殖有关的因子,包含肿瘤细胞所产生的4种特有物质,在早期恶性肿瘤患者血液中TSGF水平明显升高[1].原发性肝癌PHC(primaryhepaticcancer,PHC)是我国常见恶性肿瘤之一,其在发生发展过程中有多种癌基因被激活.实验室诊断原发性肝癌目前最常用的肿瘤标志物是甲胎蛋白AFP(AlphaFetoprotein,AFP),AFP是胎儿时期肝脏合成的一种胚胎蛋白,正常成人肝细胞不产生.据报AFP,而当肝细胞癌变后,AFP又重新表达
及免疫检验确诊.
1.2 方法及仪器
清晨空腹抽取静脉血2mL,3000r
第19卷 第3期甘肃科学学报Vol.19 No.3
2007年9月JournalofGansuSciencesSep.2007
TSGF与AFP对原发性肝癌的诊断特异性、
灵敏度分析
齐心亮,樊红艳,张 萍,朱小红,彭俊华,张华欣
(兰州军区兰州总医院检验科,甘肃兰州 730050)
摘 要: 分析探讨TSGF与AFP检测在原发性肝癌诊断中的特异性和灵敏度,以及对原发性肝癌的早期诊断价值.采用分光光度法检测TSGF,包括87例原发性肝癌(男性54、女性33例、平均年龄67岁)、67例继发性肝癌(男性42例、女性25例、平均年龄63岁),105例).其结果AFP.对照检测179例肝病患者的TSGF、AFP(肝硬化患者例TSGF对原发性肝癌的敏感性(86.2%)高于AFP(71.05);TSGF对继发性肝癌的敏感性(88.1%)高于AFP(35.8%)0.二者联合检测敏感性提高至94.3%.由此证明TSGF,对原发性肝癌其灵敏度高于AFP,特异性低于AFP.,对原发性肝
关键词: T;;特异性;分析
中图分类号: R13,P73517 文献标识码: A 文章编号:100420366(2007)0320088203
AnAnalysisofSpecificityandSensitivityofDiagnosisonPrimaryHepaticCarcinomabyDetectingTSGFandAFP
QIXin2liang,FANHong2yan,ZHANGPing,ZHUXiao2hong,PENGJun2hua,ZHANGHua2xin
(SectionInspectionofLaboratoryLanzhouGeneralHospital,LanzhouCommand,Lanzhou730050,China)
Abstract: OurobjectiveistoanalyzethespecificityandsensitivityofdiagnosisonprimaryhepaticThelevelofTSGFwasdetectedbythespectrophotometric
methodappliedto87primaryhepaticcarcinomapatients(male:54,female:33,averageage:67)and67secondumhepaticcarcinomapatients(male:42,female:25,averageage:63).Meanwhile,thelevelofAFPwasdetectedbythechemiluminescencemethod,andthelevelofTSGFandAFPweredetectedin179hepatopathycases(hepaticcirrhosis:74,chronictypeBhepatitis:105)ascomparison.Theresultsshow:thesensitivity(86.2%)ofdiagnosisonprimaryhepaticcarcinomabydetectingTSGFishigherthanthat(71.4%)bydetectingAFP,whichisstatisticallysignificant(P
: TSGF;AFP;primaryhepaticcarcinoma,specificity,analysiscarcinomabydetectingTSGFandAFP.
收稿日期:2006-01-30
恶性肿瘤特异生长因子TSGF(Tumorspecificgrowthfactor,TSGF)是近年来发现的一组与恶性肿瘤血管增殖有关的因子,包含肿瘤细胞所产生的4种特有物质,在早期恶性肿瘤患者血液中TSGF水平明显升高[1].原发性肝癌PHC(primaryhepaticcancer,PHC)是我国常见恶性肿瘤之一,其在发生发展过程中有多种癌基因被激活.实验室诊断原发性肝癌目前最常用的肿瘤标志物是甲胎蛋白AFP(AlphaFetoprotein,AFP),AFP是胎儿时期肝脏合成的一种胚胎蛋白,正常成人肝细胞不产生.据报AFP,而当肝细胞癌变后,AFP又重新表达
及免疫检验确诊.
1.2 方法及仪器
清晨空腹抽取静脉血2mL,3000r