NRR-D-15-00647 Florian Simon 新闻
脊髓缺血再灌注损伤后截瘫模型的优化选择
来自德国杜塞尔多夫大学的Florian Simon博士认为，在构思搭建一项动物实验模型时需要考虑几个方面的问题：首先要认识到实验模型仅仅是对临床环境的模拟尝试，在将实验结果应用到人体上时还需要进行充分的讨论。同时，还要知道并不存在完美无缺的实验模型。要想加深对某个临床问题或副作用问题的了解，就需要搭建多个实验模型，在其中选择最适合的一个，也就是说，要在实验前对所研究问题进行缜密的构思。在新建一项实验模型时，应明确查阅文献无法与有相关经验的科研人员进行团队合作相媲美。因为微观管理方式的差异，实验得出的结果通常都有异于其他团队结果描述。因此，Simon博士认为，构建实验模型的诀窍在于必须亲自实验，提高自身的专业技能。该文章发表在《中国神经再生研究（英文版）》2016年3期杂志上。
Article: "Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine
postischemic paraplegia" by Florian Simon, Alexander Oberhuber (Clinic for Vascular- and Endovascular Surgery, Heinrich-Heine-University, Düsseldorf, Germany)
Simon F, Oberhuber A (2016) Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine postischemic paraplegia. Neural Regen Res 11(3):414-415.
欲获更多资讯：请与《中国神经再生研究（英文版）》杂志国际发展部联络；联络电话：+[1**********]73，或用电子邮件联络：eic@nrren.org。 文章全文请见：http://www.nrronline.org/
中文摘要
在构思搭建一项动物实验模型时需要考虑几个方面的问题。第一个要点是要认识到实验模型仅仅是对临床环境的模拟尝试，在将实验结果应用到人体上时还需要进行充分的讨论。同时，还要认识到完美无缺的实验模型是不存在的。要想加深对某个临床问题或副作用问题的了解，就需要搭建多个实验模型，在其中选择最适合的一个，这就意味着需要在实验前对所研究问题进行缜密的构思。在新建一项实验模型时，应当知道查阅文献是不能替代与有相关经验的科研人员进行团队合作的。实验得出的结果通常都有异于其他工作团队的文献记载，这是因为微观管理方式都不尽相同。所以，我们得出的结论就是必须要亲自进行实验，提高自身的专业技能。
英文摘要
There are several aspects one should consider if thinking about building up an animal model. First of all it is important to understand that experimental models are only an attempt to mimic clinical situation and require a lot of discussion when conclusions are to be drawn with a view to humans. There will never be an ideal model. For a deeper understanding of a clinic problem or side-effect several models are needed so that the best fitting one can be chosen. This indicates that a precise formulation of the question to be answered is needed in advance. It requires a rather big budget, a lot of time and manpower to realise a large animal model that should take place in an animal intensive care. At the same time this has the benefit of more clinical relevant data acquisition. For those needing a simple model that is easy to learn and only needs an animal operation theatre but no animal intensive care unit, the rabbit model might be the right choice. It combines the small surgical impact with the possibility of long-time postoperative observation. When looking at questions dealing with DNA focus or needing animals of genetically altered strains the mouse model will fit best as it offers these advantages that normally cannot be found in other animal models. Eventually, when building up a new model one should take into account that research in literature will not replace teamwork with already experienced scientists in this field. Results will always differ from literature of other groups, because micromanagement differs. So each new experiment, especially when using a new animal model, needs a learning curve for building up one’s own know-how.
NRR-D-15-00647 Florian Simon 新闻
脊髓缺血再灌注损伤后截瘫模型的优化选择
来自德国杜塞尔多夫大学的Florian Simon博士认为，在构思搭建一项动物实验模型时需要考虑几个方面的问题：首先要认识到实验模型仅仅是对临床环境的模拟尝试，在将实验结果应用到人体上时还需要进行充分的讨论。同时，还要知道并不存在完美无缺的实验模型。要想加深对某个临床问题或副作用问题的了解，就需要搭建多个实验模型，在其中选择最适合的一个，也就是说，要在实验前对所研究问题进行缜密的构思。在新建一项实验模型时，应明确查阅文献无法与有相关经验的科研人员进行团队合作相媲美。因为微观管理方式的差异，实验得出的结果通常都有异于其他团队结果描述。因此，Simon博士认为，构建实验模型的诀窍在于必须亲自实验，提高自身的专业技能。该文章发表在《中国神经再生研究（英文版）》2016年3期杂志上。
Article: "Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine
postischemic paraplegia" by Florian Simon, Alexander Oberhuber (Clinic for Vascular- and Endovascular Surgery, Heinrich-Heine-University, Düsseldorf, Germany)
Simon F, Oberhuber A (2016) Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine postischemic paraplegia. Neural Regen Res 11(3):414-415.
欲获更多资讯：请与《中国神经再生研究（英文版）》杂志国际发展部联络；联络电话：+[1**********]73，或用电子邮件联络：eic@nrren.org。 文章全文请见：http://www.nrronline.org/
中文摘要
在构思搭建一项动物实验模型时需要考虑几个方面的问题。第一个要点是要认识到实验模型仅仅是对临床环境的模拟尝试，在将实验结果应用到人体上时还需要进行充分的讨论。同时，还要认识到完美无缺的实验模型是不存在的。要想加深对某个临床问题或副作用问题的了解，就需要搭建多个实验模型，在其中选择最适合的一个，这就意味着需要在实验前对所研究问题进行缜密的构思。在新建一项实验模型时，应当知道查阅文献是不能替代与有相关经验的科研人员进行团队合作的。实验得出的结果通常都有异于其他工作团队的文献记载，这是因为微观管理方式都不尽相同。所以，我们得出的结论就是必须要亲自进行实验，提高自身的专业技能。
英文摘要
There are several aspects one should consider if thinking about building up an animal model. First of all it is important to understand that experimental models are only an attempt to mimic clinical situation and require a lot of discussion when conclusions are to be drawn with a view to humans. There will never be an ideal model. For a deeper understanding of a clinic problem or side-effect several models are needed so that the best fitting one can be chosen. This indicates that a precise formulation of the question to be answered is needed in advance. It requires a rather big budget, a lot of time and manpower to realise a large animal model that should take place in an animal intensive care. At the same time this has the benefit of more clinical relevant data acquisition. For those needing a simple model that is easy to learn and only needs an animal operation theatre but no animal intensive care unit, the rabbit model might be the right choice. It combines the small surgical impact with the possibility of long-time postoperative observation. When looking at questions dealing with DNA focus or needing animals of genetically altered strains the mouse model will fit best as it offers these advantages that normally cannot be found in other animal models. Eventually, when building up a new model one should take into account that research in literature will not replace teamwork with already experienced scientists in this field. Results will always differ from literature of other groups, because micromanagement differs. So each new experiment, especially when using a new animal model, needs a learning curve for building up one’s own know-how.